Joint Final Report of Phase III trials Demonstrate Positive Outcomes from Combination of PCV Chemotherapy and RT in Patients with Anaplastic Oligodendroglial Tumors
The addition of procarbazine, lomustine, and vincristine chemotherapy to radiation therapy (RT) was shown to lengthen both disease control and survival relative to RT alone as first-line therapy following surgery
Additional Taxane Maintenance Therapy Does Not Successfully Improve Overall Survival for Women with Advanced Ovarian, Peritoneal, and Tubal Cancers
NRG GOG-0212 indicated that treating women who received complete clinical response after first-line platinum-taxane therapy with single-agent taxane maintenance therapy only slightly improved progression-free survival—but did not improve overall survival—and lead to significant adverse events
Adjuvant Everolimus Benefit in High-Risk RCC
S0931 found everolimus after surgery tended to increase recurrence-free survival time in patients with high-risk kidney cancer, although results narrowly missed reaching statistical significance
Drug Combo Improved Survival in NSCLC
Ramucirumab plus pembrolizumab combination reduced risk of death by 31 percent compared to standard of care in patients with advanced non-small cell lung cancer that had progressed on prior immunotherapy
Medicaid Expansion Impact on SWOG Trials
Affordable Care Act’s expansion of Medicaid in 2014 was followed by a significant rise in proportion of enrollees in group’s cancer trials insured by Medicaid
ECOG-ACRIN research highlights at ASCO 2022
Researchers with the ECOG-ACRIN Cancer Research Group will present a wide range of abstracts at the annual meeting of the American Society of Clinical Oncology (ASCO)
Cell-Free DNA Predicts Bladder Chemo Benefit
SWOG researchers have used methylation patterns in cell-free DNA from blood samples to predict which patients with muscle-invasive bladder cancer are likely to benefit from neoadjuvant chemo and which patients can safely skip it
Standing Physician Orders Don’t Help CSF RXs
Adding standing physician orders to electronic record systems did not improve adherence to guidelines for prophylactic prescribing of colony-stimulating factors for febrile neutropenia and did not lower the rate of the chemotherapy side effect
Desmoplastic Melanoma Responds to IO Therapy
A high rate of response to neoadjuvant PD-1 blockade in patients with desmoplastic melanoma suggests such therapy could reduce the extent of surgery needed on the face and neck
Alliance NCTN/NCORP/AFT at 2022 ASCO
Alliance investigators will present more than 20 abstracts, sharing the latest findings on breast cancer, lung cancer, GI and GU cancers, along with cancer control research